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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MCM4
All Species:
39.7
Human Site:
Y670
Identified Species:
62.38
UniProt:
P33991
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P33991
NP_005905.2
863
96558
Y670
A
H
H
L
V
A
L
Y
Y
Q
S
E
E
Q
A
Chimpanzee
Pan troglodytes
XP_528129
863
96543
Y670
A
H
H
L
V
A
L
Y
Y
Q
S
E
E
Q
A
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_535063
929
104136
Y736
A
H
H
L
V
A
L
Y
Y
R
S
E
E
Q
M
Cat
Felis silvestris
Mouse
Mus musculus
P49717
862
96718
Y669
A
H
H
L
V
S
L
Y
Y
Q
S
E
E
Q
V
Rat
Rattus norvegicus
NP_387500
862
96552
Y669
A
H
H
L
V
S
L
Y
Y
Q
S
E
E
Q
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515513
863
97108
Y670
A
H
H
L
V
A
L
Y
Y
Q
S
E
E
Q
M
Chicken
Gallus gallus
XP_424376
859
96866
Y666
A
R
H
L
V
S
L
Y
Y
Q
S
E
E
K
L
Frog
Xenopus laevis
P30664
863
97105
Y670
A
H
H
L
V
A
L
Y
Y
Q
S
E
E
Q
M
Zebra Danio
Brachydanio rerio
NP_944595
750
84021
V572
T
R
S
V
L
H
E
V
M
E
Q
Q
T
L
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q26454
866
96592
Y672
A
S
H
L
V
S
L
Y
Y
V
T
R
H
E
E
Honey Bee
Apis mellifera
XP_624670
636
71159
K458
P
E
R
I
E
T
L
K
L
L
S
Q
K
K
D
Nematode Worm
Caenorhab. elegans
Q21902
759
84917
K581
L
T
I
E
F
L
K
K
F
V
T
Y
A
R
L
Sea Urchin
Strong. purpuratus
XP_801985
910
101460
Y717
A
N
H
L
V
S
L
Y
H
Q
G
T
Q
E
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P43299
716
80315
T538
H
V
L
H
V
H
Q
T
E
E
S
P
A
L
G
Baker's Yeast
Sacchar. cerevisiae
P30665
933
104985
Y728
A
K
H
L
T
N
L
Y
L
E
D
K
P
E
H
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
N.A.
87.6
N.A.
94.9
95.1
N.A.
92.4
86.3
85.7
71.3
N.A.
60.1
42.1
28.1
63.3
Protein Similarity:
100
100
N.A.
90
N.A.
97
97.3
N.A.
96.1
93.1
92.9
78.7
N.A.
77.3
54.3
46.9
76.3
P-Site Identity:
100
100
N.A.
86.6
N.A.
86.6
86.6
N.A.
93.3
73.3
93.3
0
N.A.
46.6
13.3
0
46.6
P-Site Similarity:
100
100
N.A.
93.3
N.A.
93.3
93.3
N.A.
93.3
86.6
93.3
33.3
N.A.
66.6
40
20
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
28.9
42.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
46.5
62.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
33.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
74
0
0
0
0
34
0
0
0
0
0
0
14
0
14
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
7
% D
% Glu:
0
7
0
7
7
0
7
0
7
20
0
54
54
20
7
% E
% Phe:
0
0
0
0
7
0
0
0
7
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
7
% G
% His:
7
47
74
7
0
14
0
0
7
0
0
0
7
0
7
% H
% Ile:
0
0
7
7
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
7
0
0
0
0
7
14
0
0
0
7
7
14
0
% K
% Leu:
7
0
7
74
7
7
80
0
14
7
0
0
0
14
14
% L
% Met:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
20
% M
% Asn:
0
7
0
0
0
7
0
0
0
0
0
0
0
0
0
% N
% Pro:
7
0
0
0
0
0
0
0
0
0
0
7
7
0
0
% P
% Gln:
0
0
0
0
0
0
7
0
0
54
7
14
7
47
0
% Q
% Arg:
0
14
7
0
0
0
0
0
0
7
0
7
0
7
0
% R
% Ser:
0
7
7
0
0
34
0
0
0
0
67
0
0
0
7
% S
% Thr:
7
7
0
0
7
7
0
7
0
0
14
7
7
0
7
% T
% Val:
0
7
0
7
74
0
0
7
0
14
0
0
0
0
14
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
74
60
0
0
7
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _